WebAug 9, 2024 · Here, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain- and loss-of-function studies across multiple murine and human tumor types, we show that opposite pro- or anti-cancer YAP activity functionally defines binary YAPon or … WebJun 21, 2024 · The binary cancer groups exhibit distinct YAP-dependent adhesive behavior, and pharmaceutical vulnerabilities, underscoring clinical relevance. …
Binary pan-cancer classes with distinct vulnerabilities
WebJul 8, 2024 · Small-cell neuroendocrine cancers (SCNCs) are an aggressive cancer subtype. Transdifferentiation toward an SCN phenotype has been reported as a resistance route in response to targeted therapies. Here, we identified a convergence to an SCN state that is widespread across epithelial cancers and is as … WebMar 30, 2024 · Sorted in a descending order, distinct differences were found for the prevalence of different cancer types and histograms roughly show a power-law (long-tail) distribution trend. That is, a few cancer types at the head occupy the majority of the sample, while many categories at the tail occupy only a small portion of the total sample. thimble\\u0027s va
Binary pan-cancer classes with distinct vulnerabilities defined by pro
WebMay 7, 2024 · Colorectal cancer (CRC) is a common gastrointestinal malignancy, which is the third most commonly diagnosed cancer in males and the second one in females worldwide 1.Yes-associated protein (YAP ... WebCompacting Binary Neural Networks by Sparse Kernel Selection Yikai Wang · Wenbing Huang · Yinpeng Dong · Fuchun Sun · Anbang Yao Bias in Pruned Vision Models: In-Depth Analysis and Countermeasures Eugenia Iofinova · Alexandra Peste · Dan Alistarh X-Pruner: eXplainable Pruning for Vision Transformers Lu Yu · Wei Xiang Deep Graph … WebHere, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain- and loss-of-function studies across multiple murine and human tumor types, we show that opposite pro- or anti-cancer YAP activity functionally defines binary YAPon or YAPoff ... saint of a woman