WebFeb 16, 2001 · The interstrand crosslinks may contribute to the biological and pathological effects that UV irradiation is known to bring about. Here alkaline agarose gel electrophoresis was used to assess the crosslinked fraction of 31 selected restriction fragments of six viral and plasmid DNA molecules exposed to UVC light irradiation. WebNational Center for Biotechnology Information
REV1 and DNA polymerase zeta in DNA interstrand crosslink repair
WebDNA interstrand cross-links are complex lesions, highly toxic to cells, and difficult to repair because of the involvement of both strands of the DNA duplex. A single unrepaired inter-strand cross-link is sufficient to kill a cell, and multiple DNA repair pathways may be required to complete cross-link re-moval (1–7). WebLoss of C17orf53 slowed down DNA replication and led to pronounced interstrand crosslink (ICL) repair defect. We showed that C17orf53 is a ssDNA- and RPA-binding protein and both characteristics are important for its functions in the cell. blackstone alternative solutions 2016 trust
Upasana Roy, Ph.D. - Science Program Manager - LinkedIn
WebJan 24, 2024 · Fanconi anemia is an inherited genomic instability disorder caused by mutations in genes regulating replication-dependent removal of interstrand DNA crosslinks 25. Accordingly, in response to ... WebMar 16, 2024 · The Fanconi anemia (FA) pathway is known for its role in DNA interstrand crosslink (ICL) repair . In addition to its pathological relevance to the genetic disorder of Fanconi anemia, the FA pathway has been overwhelmingly positioned in the context of cancer [ 7 , 8 ], suggesting that targeting the FA pathway is a prospective avenue for … WebAug 12, 2009 · The C4'-oxidized abasic site (C4-AP) is a commonly formed DNA lesion, which generates two types of interstrand cross-links (ICLs). The kinetically favored cross-link consists of two full length strands and forms reversibly and exclusively with dA. Cross-link formation is attributed to condensation of C4-AP with the N6-amino group of dA. blackstone air fryer grill combo