2024 Gsea autophagy

Gsea autophagy

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August undefined, 2024

WebApr 12, 2024 · Terms such as autophagy (GO:0006914) process utilizing autophagic mechanism (GO:0061919), positive regulation of autophagy (GO:0010508), and autophagosome assembly (GO:0000045) were suppressed in GSEA (Fig. 3A). These results suggest that thrombin may reduce cholesterol efflux by affecting lipid hydrolysis … WebOct 14, 2024 · b Autophagy-related pathways based on GSEA REACTOME analysis using the same data as in (a). FDR and NES are presented as a bar graph (NES >1.25, FDR <0.25). FDR and NES are presented as a bar ...

REACTOME_CHAPERONE_MEDIATED_AUTOPHAGY - GSEA

WebMar 23, 2024 · Optineurin (OPTN) is a conserved protein that has been identified as an autophagy receptor and plays a central role in selective autophagy. It has been reported that OPTN, as a receptor, is generally recruited into ubiquitin-coated depolarized mitochondria and has been shown to be a major molecule necessary for mitophagy ( … WebAug 13, 2024 · Autophagy has been associated with oncogenesis with one of its emerging key functions being its contribution to the metabolism of tumors. ... GSEA was performed … team portnoy jumpsuit jacket

WP_AUTOPHAGY - GSEA MSigDB

WebThe GSEA analysis results show that ribosomal biological processes and photosynthesis-related pathways are obviously enriched in the three stages, and photosynthesis-related pathways are the main biological processes with down-regulation in the three stages. ... Besides, we discovered that the autophagy and the RNA degradation process was ... WebMay 1, 2024 · GSEA suggested that autophagy was enhanced in ovarian cancer cells under lnc-CTSLP8 overexpression (Fig. 3a). TEM revealed greater numbers of enlarged … WebNov 10, 2024 · The Gene Set Enrichment Analysis (GSEA) showed that the gene sets related to autophagy are significantly differentially expressed among the paired normal tissues and RCC. Multivariate and univariate Cox analyses were used to construct the gene signature related to prognosis. ekom bra

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GeneSetEnrichmentAnalysisWiki - Broad Institute

WebCompendia expression profiles ?: GTEx compendium Human tissue compendium (Novartis) Global Cancer Map (Broad Institute) NCI-60 cell lines (National Cancer Institute): Advanced query: Further investigate these 30 genes : Gene families ?: Categorize these 30 genes by gene family : Show members (show 30 members mapped to 30 genes) WebJan 8, 2024 · The autophagy gene list was obtained from human autophagy database . The gene candidates in this database have been reported to directly or indirectly involve in autophagy. Through a GSEA, autophagy was found to be significantly enriched in the high-DDIT4-expression group (Fig. 6A). ekom brno ekom arenzano orari

"WebDec 7, 2024 · Autophagy, a highly conserved cellular proteolysis process, has been involved in non-small cell lung cancer (NSCLC). We tried to develop a prognostic … " - Gsea autophagy

Gsea autophagy

WebMar 5, 2024 · GSEA was used to identify pathways (KEGG, Reactome, STKE and PID) significantly altered between recovery time-points 6 h and 24 h, compared to 0 h using … WebApr 10, 2024 · The Coatomer protein complex Zeta 1 (COPZ1) has been reported to play an essential role in maintaining the survival of some types of tumors. In this study, we sought to explore the molecular characteristics of COPZ1 and its clinical prognostic value through a pan-cancers bioinformatic analysis. We found that COPZ1 was extremely prevalent in a …

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WebMay 1, 2024 · Gene Set Enrichment Analysis (GSEA) was used for gene function annotation. Single-cell RNA-sequencing Fresh ovarian cancer tissue, adjacent ovarian tissue, and peritoneal metastasis tissue samples were cut into small pieces and then enzymatically digested using the MACS tumor dissociation kit (Miltenyi Biotec, Germany). WebOct 21, 2024 · Identification of Autophagy-Related Messenger RNAs in Neuroblastoma. A total of 694 autophagy-related encoding genes were obtained from the Human Autophagy Database (HADb 5) and the Molecular Signatures Database of Gene Set Enrichment Analysis (GSEA 6). Next, 643 ATG mRNAs were identified by mRNAs of the training …

WebThe seven autophagy-related signatures predicted the OS of patients with RCC correctly, exhibiting a significant potential for clinical applications, including custom prediction and … WebSep 2, 2024 · The coexpression network of lncRNAs and autophagy-related genes was utilized to select autophagy-related lncRNAs. The lncRNAs were further screened using univariate Cox regression. In addition, Lasso regression and multivariate Cox regression were used to develop an autophagy-related lncRNA signature.

WebThe seven autophagy-related signatures predicted the OS of patients with RCC correctly, exhibiting a significant potential for clinical applications, including custom prediction and treatment. A study of GSEA enhancements showed substantial variations between risky and low-risk groups considering the autophagic signal pathways. WebJul 8, 2024 · In addition, we recently found that mTOR is involved in the regulation of autophagy and muscle protein degradation under hypoxic conditions (Chen et al., 2024). It is essential to investigate the effects of mTOR on muscle cells to gain a better understanding of myogenesis. ... GSEA Showed Enriched Among Differentially …

WebGene Set Enrichment Analysis (GSEA) is a computational method that determines whether an a priori defined set of genes shows statistically. significant, concordant differences …

WebFor the Mouse gene set with the same name, see GOBP_SELECTIVE_AUTOPHAGY. Standard name. GOBP_SELECTIVE_AUTOPHAGY. Systematic name. M24317. Brief description. The macroautophagy process in which specific structures are targeted by the autophagy process. [PMID:20484971, PMID:21997368, PMID:22966490] ekolurra normativaWeb36 rows · Human Gene Set: KEGG_REGULATION_OF_AUTOPHAGY. Standard name. KEGG_REGULATION_OF_AUTOPHAGY. Systematic name. M6382. Brief description. … team possabilities loma lindaWebDec 17, 2024 · Keywords: GSEA; autophagy; gene signature; glioblastoma; prognostic model. Publication types MeSH terms Autophagy / genetics Autophagy / physiology* Databases, Genetic Gene Expression Regulation, Neoplastic Genetic Testing* Glioblastoma / metabolism* Glioblastoma / pathology* Humans Nomograms* Prognosis Reproducibility … team poly slimline tanksWebMar 3, 2024 · If you have a question, see the FAQ or the User Guide. The User Guide describes how to prepare data files, load data files, run the gene set enrichment analysis, and interpret the results. It also includes instructions for running GSEA from the command line and a Quick Reference section, which describes each window of the GSEA desktop … team possible nimsWebNational Center for Biotechnology Information ekom calusoWebCompendia expression profiles ?: GTEx compendium Human tissue compendium (Novartis) Global Cancer Map (Broad Institute) NCI-60 cell lines (National Cancer Institute): … ekom campomorone orariWebAug 11, 2024 · Gene set enrichment analysis (GSEA) ... Autophagy alleviates oxidative stress by eliminating damaged mitochondria and ROS in a process called mitophagy . To investigate if autophagy activity was different in TAM subsets in response to high OXPHOS, we treated macrophages with chloroquine (CQ), an autophagy inhibitor, to prevent … team powerhouse pikeville ky