Htra3 heart
WebRecombinant Human HtrA3 protein (His tag) is an Escherichia coli Protein fragment 132 to 353 aa range, > 95% purity and validated in WB, SDS-PAGE. Recombinant Human … Web1 jul. 2024 · HtrA3 is a proapoptotic protease shown to promote drug-induced cytotoxicity in lung cancer cells and proposed to have an antitumor effect. ... Caspases involved in the initiation and execution phase of apoptosis are at the heart of the apoptosis pathway. The caspase enzymatic activity at both the initiation (caspase-9) ...
Htra3 heart
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Web4 jul. 2024 · High temperature requirement factor A3 (HtrA3), a member of the HtrA protease family, is highly expressed in the developing placenta, including the maternal decidual cells in both mice and humans. WebHTRA3 protein expression summary - The Human Protein Atlas. HTRA3. PROTEIN SUMMARY SECTION OVERVIEW RNA DATA ANTIBODY DATA. HTRA3 …
WebHTRA3 (Prsp, Tasp) protein expression summary. Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decori n/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). Web8 nov. 2024 · Htra3 deletion in the murine heart caused overactivation of TGF-β signalling which induced not only significant cardiac fibrosis, but also cardiomyocyte senescence …
Web17 jun. 2004 · The differential expression of HtrA1 and -3 could also be seen in other embryonic tissues. In E16.5 embryo heart, a weak expression of HtrA1 was detected by northern blot but HtrA3 was barely expressed . In the E14.5 heart, HtrA1 but no HtrA3 was detected distinctly in the endocardial cushion (Fig. 4a and c). Web18 jan. 2024 · Collectively, we identified that hsa-miR-494-3p, a miRNA induced in both circulation of AKI patients and hypoxia-reoxygenation-treated HK2 cells, enhanced renal inflammation by targeting HtrA3, which may suggest a possible role as a new therapeutic target for CSA-AKI. Publication types Research Support, Non-U.S. Gov't MeSH terms
WebThe long isoform, HTRA3L, contains 453 amino acids and has a predicted molecular mass of 49 kD. It contains an N-terminal signal peptide, followed by an insulin/IGF (see 147440 …
Web28 aug. 2024 · HtrA3 knockout mice show that HtrA3 in cardiac fibroblast is essential for preventing TGFβ signaling activation, interstitial fibrosis, and cardiac dysfunction after … thomas shelby ginWeb1 okt. 2024 · Another component of HTRAs family is HTRA3, it is weakly expressed in brain tissue while a high expression it was found in adult heart, fetal heart, ovary and placenta (Nie et al., 2003a). Moreover, HTRA3 is also expressed in the endometrium, in particular it is highly expressed during late secretory phase of the menstrual cycle, when the … thomas shelby gangWeb1 apr. 2003 · In the present study, we identified an additional member of the human high-temperature requirement factor A (HtrA) protein family, called pregnancy-related serine … uk bass legislationWeb6 dec. 2024 · CSB depletion promotes overexpression of the HTRA3 protease resulting in ... TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging. 02 ... thomas shelby gin labelWebDownloadable! Tissue fibrosis and organ dysfunction are hallmarks of age-related diseases including heart failure, but it remains elusive whether there is a common pathway to induce both events. Through single-cell RNA-seq, spatial transcriptomics, and genetic perturbation, we elucidate that high-temperature requirement A serine peptidase 3 (Htra3) is a critical … ukba sponsorship listWeb23 dec. 2024 · HtrA serine peptidase 3 (HTRA3) participates in multiple signal pathways and plays an important regulatory role in various malignancies; however, its role on prognosis and immune infiltrates in gastric cancer (GC) remains unclear. The study investigated HTRA3 expression in tumor tissues and its association with immune infiltrates, and … thomas shelby hat razorWebView Rabbit Polyclonal anti-HtrA3 Antibody (NB600-1151). Validated Applications: WB, ICC/IF. Validated Species: Human, Mouse, Rat + more. Sample size available. ... Yamada S et al. Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-beta-IGFBP7 axis Nature communications Jun 7 2024 [PMID: 35672400] (WB, Mouse) WB: uk baskettball schedule feb. 26 2022