Klf5 is required
WebAug 15, 2008 · Our results demonstrate that Klf5 is an essential factor of the core regulatory network that maintains ESCs in the undifferentiated state. Klf5 KD does not modify levels of Klf2 and Klf4, thus suggesting that the presence of these two factors cannot completely substitute for the reduction or absence of Klf5. WebHere, we show that the Klf5-deficient embryos fail to implant due to defective trophectoderm development.We also show that Klf5 is required for the derivation of ESCs from ICM cells. Interestingly, Klf5-deficient ESCs can be established by knocking out both Klf5 alleles in mouse ESCs. The Klf5 knockout (KO) ESCs can maintain pluripotency but show increased …
Klf5 is required
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WebDec 15, 2024 · These data support that KLF5 is required for ADM and oncogenic KRAS-induced PanIN formation. Ndrg2 is a gene of interest detected by the RNA sequencing and validated by qRT-PCR and Western blot, and it is up-regulated in the Klf5-deleted mice 2 days after cerulein-induced pancreatitis . NDRG2 is a member of a family of alpha/beta … WebAbstract Krüppel-like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and …
WebAug 15, 2008 · Our results demonstrate that Klf5 is an essential factor of the core regulatory network that maintains ESCs in the undifferentiated state. Klf5 KD does not modify levels … WebOct 1, 2011 · In the present study, we demonstrate that KLF5 is required for normal maturation of the murine bladder urothelium and suggest that Grhl3 and Pparγ are candidate transcriptional downstream targets that mediate this process. Deletion of Klf5 from the developing bladder urothelium causes prenatal VUR, hydroureter, and hydronephrosis.
WebJul 29, 2014 · Rapid replacement of Klf5-mutant crypts with wildtype cells and reduction of stem cell markers suggests further that Klf5 is required for self renewal of intestinal stem cells. Discover the world ... WebJan 5, 2024 · Androgen deprivation resistance is the final common step of many advanced prostate cancers. Li et al. identified the key promoting role of KLF5, the transcription factor Krüppel-like factor 5, in the androgen-AR signaling of LNCaP and C4-2B prostate cell lines. The authors considered this effect as a potential target to develop new therapeutic ...
WebThis website you visit will use cookies in order to improve your user experience by enabling that website to ‘remember’ you. Should you continue navigating we will consider that you accept their use. fetch full seriesWebAbstract Krüpple-like factor 5 (KLF5) is required for the development of the embryo and multiple organs, such as the lung and intestine. KLF5 plays a pro-proliferative and … delray beach internet marketing companyWebOct 1, 2011 · KLF5 is required for stratification and terminal differentiation of urothelial cells. Defects in urothelial maturation induces hydronephrosis. KLF5 is not required for maturation of the bladder neck and urethral epithelium. Grhl3 and Pparγ are candidate targets of … delray beach hotel suitesWebHere, we show that Klf5 is required for the formation of the trophectoderm (TE) and the inner cell mass (ICM), and for repressing primitive endoderm (PE) development. Although cell polarity appeared normal, Klf5 mutant embryos arrested at the blastocyst stage and failed to hatch due to defective TE development. delray beach homes for sale 33444WebKrüppel-like factor 5 (KLF5) is a zinc-finger transcription factor known to play a pivotal role in the pathogenesis of cardiovascular disease. Here, we show that neonatal heterozygous KLF5 knockout mice exhibit a marked deficiency in white adipose tissue development, suggesting that KLF5 is also required for adipogenesis. delray beach hotels with kitchensWebOct 15, 2016 · Klf5 is also required for adipocyte differentiation. In 3T3-L1 preadipocytes, Klf5 is induced at an early stage of differentiation by C/EBPβ and δ, which is followed by expression of PPARγ 2 ( Oishi et al., 2005 ). We previously reported that Klf5 acts as a regulator of lipid metabolism in skeletal muscle ( Oishi et al., 2008 ). delray beach hotelsWebDec 1, 2010 · Klf5 is required for normal mouse pre-implantation development. (A) Confocal cross-sections showing DIC images (top) and Klf5 (middle) and Draq5 nuclei (bottom) … delray beach independent living communities